Fixing the IE7 ‘Run Once’ Problem
Go to Start > Run > and type “gpedit.msc”, press enter.
“User Configuration” – > “Administrative Templates” – > “Internet Explorer->”Prevent performance of First Run Customize settings”.
Open that option and change the settings to “Enabled” -> “Go Directly to your homepage”.
Group Policy Editor might not have any effect on the computers that has disabled it. You can use this registry hack to disable the runonce annoyance.
Start regedit.exe from Start –> Run and find the key:
HKEY_CURRENT_USER\Software\Microsoft\Internet Explorer\Main
Change the “RunOnceHasShown” on the right to: 1
geekpedia 
To do this through GPO’s in an ADS environment, set the following Computer policy:
Test PA Standard User Policy
User Configuration -> Admin Templates -> Windows Components -> Internet Explorer -> “Prevent performance of First Run Customize settings” set to Enabled/Go Directly to your Homepage.
Thanks for this I’d been searching for ages to try and sort this out for terminal services and ie7. Finally fixed using GPE.
HKEY_CURRENT_USER\Software\Microsoft\Internet Explorer\Main
Set (or create DWORD) both of these:
“RunOnceHasShown” = 1
“RunOnceComplete” = 1